Percutaneous Transcatheter Left Atrial Appendage Exclusion in Atrial Fibrillation

Chiam Paul, Ruiz CE.

Journal of Invasive Cardiology 2008; 20: E109-13.


Stroke is one of the leading causes of mortality, morbidity and serious disability in the developed world. Atrial fibrillation (AF), one of the most common cardiac arrhythmias, is a well-known predisposing factor for stroke, raising the risk significantly. Oral anticoagulation with warfarin is currently the most effective therapy for stroke risk reduction; however, this therapy increases the risk of bleeding and is often underutilized, contraindicated, or when administered, often subtherapeutic. It has been documented that the left atrial appendage (LAA) is the main source of leftatrial thrombus, especially in non-rheumatic AF. Therefore, LAA exclusion may reduce the risk of stroke in AF, and retrospective surgical data have demonstrated a reduced risk of embolic events if surgical LAA exclusion was also performed during mitral valve replacement. Recently, several less invasive percutaneous transcatheter techniques of LAA exclusion – the PLAATO device, the Watchman device, and the Amplatzer Septal Occluder – have been employed with initially encouraging results. There is currently an ongoing randomized trial comparing percutaneous LAA exclusion to long-term oral anticoagulation therapy. Until such data are available, however, oral anticoagulation should remain the standard of care for stroke prevention in patients with AF.

Contact Us

Input this code: captcha

The Heart & Vascular Centre
3 Mount Elizabeth #08-06
Mount Elizabeth Medical Centre
Singapore 228510
T: (65) 6735 3022
F: (65) 6735 3021
After hours: (65) 9664 0822
* Directions

The Heart & Vascular Centre (Novena)
38 Irrawaddy Road #09-21
Mt Elizabeth Novena Specialist Centre
Singapore 329563
T: (65) 6694 0140
F: (65) 6694 0150
After hours: (65) 9236 1026
* Directions


+65 6735 3022

Call Us Now!

For an appointment.