First percutaneous transcatheter aortic valve-in-valve implant with three year follow-up

Carlos E. Ruiz MD, PhD, FACC, FSCAI, Jean C. Laborde MD, Jose F. Condado MD, Paul T.L. Chiam MBBS, MRCP and Jose A. Condado MD

Catheterization and Cardiovascular Interventions 2008; 72: 143-148.



This study was conducted to report the clinical, hemodynamic, and iconographic outcomes of the longest survivor of the global CoreValve experience.


Early results of percutaneous heart valve (PHV) implantation for severe symptomatic aortic stenosis (AS) have been encouraging, with mid term survival up to 2 years; however longer durability term is unknown. Although a PHV has been implanted in a degenerated surgical bioprosthesis, the feasibility of a PHV-in-PHV has not been demonstrated.


A patient with severe refractory heart failure due to severe aortic regurgitation (AR) and moderate AS, underwent CoreValve prosthesis implantation. The PHV was deployed too proximal into the left ventricular outflow tract, resulting in severe AR through the frame struts. Using the first PHV as a landmark, a second CoreValve was then deployed slightly distal to the first, with trivial residual paravalvular leak.


The second CoreValve expanded well with proper function. Transvalvular gradient was 8 mmHg. Both coronary ostia were patent. New mild to moderate mitral regurgitation occurred due to impingement of the anterior mitral leaflet by the first PHV. NYHA functional class improved from IV to II, maintained over the past 3 years. Echocardiography at 3 years showed normal functioning CoreValve-in-CoreValve prostheses, without AR or paravalvular leaks. Transvalvular gradient was 10 mmHg. Cardiac CT showed stable valve-in-valve protheses with no migration.


The CoreValve prosthesis has maintained proper function up to 3 years, with no structural deterioration or migration. Treating mixed aortic valve disease with predominant AR is feasible. The concept as well as durability of the first PHV-in-PHV has also been demonstrated.

Contact Us

Input this code: captcha

The Heart & Vascular Centre
3 Mount Elizabeth #08-06
Mount Elizabeth Medical Centre
Singapore 228510
T: (65) 6735 3022
F: (65) 6735 3021
After hours: (65) 9664 0822
* Directions

The Heart & Vascular Centre (Novena)
38 Irrawaddy Road #09-21
Mt Elizabeth Novena Specialist Centre
Singapore 329563
T: (65) 6694 0140
F: (65) 6694 0150
After hours: (65) 9236 1026
* Directions


+65 6735 3022

Call Us Now!

For an appointment.