Feasibility of transcatheter aortic valve implantation in systemic lupus erythematosus associated non-calcific aortic stenosis.

Krupa J, Chiam Paul, Chua YL, Ewe SH.

European Heart Journal 2013; 35: 1624.

A 56-year-old female with systemic lupus erythematosus (SLE) and antiphospholipid syndrome, with severe aortic stenosis (mean gradient 50 mmHg, valve area 0.7 cm2) was referred for transcatheter aortic valve implantation (TAVI), due to multiple comorbidities including severe thrombocytopenia, long-term steroids, and tracheostomy for upper airway obstruction. Although transoesophageal echocardiography showed a severely thickened aortic valve (Panel ASupplementary material online,Movie S1), there was negligible valve calcification on multidetector computed tomography (Panel B). During the TAVI procedure, an aortogram was performed during valvuloplasty to confirm no coronary ostial occlusion, in view of bulky native leaflets (Panel C). A 23 mm balloon-expandable Sapien XT valve (Edwards Lifesciences) was successfully implanted. Transoesophageal echocardiography confirmed a fully expanded transcatheter valve without paravalvular regurgitation (Panel D), but a flap-like structure was seen fluttering at the aortic end of the prosthesis, without causing flow turbulence (Panel E,Supplementary material online, Movie S2). At 1-month, echocardiography showed satisfactory gradient (mean 16 mmHg) and orifice area (1.3 cm2).

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